Szpak C A, Bossen E H, Linder J, Johnston W W
Acta Cytol. 1984 May-Jun;28(3):290-6.
The histologic appearance of primary small-cell carcinoma of the skin (the so-called Merkel-cell tumor) is similar to other small-cell tumors that may metastasize to the dermis. Significance has been placed on the electron microscopic appearance of this tumor since the ultrastructural features of this neoplasm are helpful in distinguishing it from most of the other neoplasms considered in the differential diagnosis. To determine whether any additional morphologic criteria might exist to distinguish this neoplasm, the fine needle aspirate appearance of a primary small-cell carcinoma of the skin was studied and compared to that of similar preparations of other small-cell tumors that could potentially involve the dermis. Cells of this unusual tumor were round and showed neither cohesiveness nor nuclear molding. Mitoses were numerous. The chromatin pattern was bland. The cytologic features of this tumor can aid in the distinction of primary small-cell carcinoma of the skin from other metastatic small-cell neoplastic lesions in the dermis of adults.
皮肤原发性小细胞癌（所谓的默克尔细胞肿瘤）的组织学表现与其他可能转移至真皮的小细胞肿瘤相似。由于该肿瘤的超微结构特征有助于将其与鉴别诊断中考虑的大多数其他肿瘤区分开来，因此人们一直重视该肿瘤的电子显微镜表现。为了确定是否存在任何其他形态学标准来区分这种肿瘤，对皮肤原发性小细胞癌的细针穿刺抽吸物外观进行了研究，并与其他可能累及真皮的小细胞肿瘤的类似标本进行了比较。这种不寻常肿瘤的细胞呈圆形，既不显示黏附性也不显示核型。有丝分裂众多。染色质模式平淡。该肿瘤的细胞学特征有助于将皮肤原发性小细胞癌与成人真皮中其他转移性小细胞肿瘤性病变区分开来。
