Marx G
Arch Geschwulstforsch. 1984;54(2):191-6.
Surgical resection of the primary tumor along with regional lymph nodes offers the best chance for cure in lung cancer. Progress in thoracic surgery in the past decade has resulted above all from the reduction of operative risk in the elderly, allowing radical operations to be carried out in older patients as well as from better planning of the extent of surgical intervention and avoiding radical intervention where it was not likely to be beneficial. Surgery is indicated as a rule up to tumor stage T3N2M0 , but account must be taken of the patient's functional reserves. Lobectomy, appears to be the method of choice. Segmental resection or tumorectomy may be indicated in patients with limited pulmonary function. Since prognosis depends largely on the tumor's histologic type, more generous indications for surgery are appropriate in the case of squamous cell carcinoma and narrower surgical indications are called for in cases of small-cell carcinoma. Mediastinoscopy allows assessment of regional metastatic spread. Remote metastases should be excluded by liver and one scintigraphy. From 1949 to 1982 a total of 2000 patients with bronchial carcinomas have undergone surgery in the Robert-R ossle -Clinic, with resections having been performed in 1,510 patients. Pneumectomy was performed in 63%, lobectomy in 35% and segmental resection in 2%. Despite broadened indications for surgery post-operative lethality was reduced to 3% during this period. In resected patients who where detected by systematic x-ray screening programs, 5 year survival rates of 38% have been achieved by surgical treatment. Asymptomatic small-cell bronchial carcinomas are cured by operation in 20% of cases. Postoperative empyemas are treated conservatively in our clinic. Further improvements in the prognosis of bronchial carcinoma can be achieved only by early diagnosis and adequate resection.
手术切除原发性肿瘤及区域淋巴结为肺癌提供了最佳的治愈机会。过去十年胸外科的进展首先源于老年患者手术风险的降低,使得老年患者也能进行根治性手术,还源于手术干预范围的更好规划以及避免在不太可能有益的情况下进行根治性干预。通常,手术适用于肿瘤分期为T3N2M0 之前的情况,但必须考虑患者的功能储备。肺叶切除术似乎是首选方法。对于肺功能有限的患者,可考虑进行肺段切除术或肿瘤切除术。由于预后很大程度上取决于肿瘤的组织学类型,对于鳞状细胞癌,手术指征可更宽松;对于小细胞癌,则需要更严格的手术指征。纵隔镜检查可用于评估区域转移扩散情况。应通过肝脏检查和一次闪烁扫描排除远处转移。1949年至1982年,罗伯特 - 罗斯勒诊所共有2000例支气管癌患者接受了手术,其中1510例进行了切除术。63%的患者进行了全肺切除术,35%的患者进行了肺叶切除术,2%的患者进行了肺段切除术。尽管手术指征有所扩大,但在此期间术后死亡率降至3%。在通过系统X线筛查计划发现的接受切除手术的患者中,手术治疗使5年生存率达到了38%。无症状的小细胞支气管癌患者中,20%可通过手术治愈。在我们诊所,术后脓胸采用保守治疗。只有通过早期诊断和充分切除,才能进一步改善支气管癌的预后。