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Photoaffinity labeling of an interferon-gamma receptor on the surface of cultured fibroblasts.

作者信息

Anderson P, Nagler C

出版信息

Biochem Biophys Res Commun. 1984 May 16;120(3):828-33. doi: 10.1016/s0006-291x(84)80181-3.

DOI:10.1016/s0006-291x(84)80181-3
PMID:6329186
Abstract

Highly purified native and recombinant 125I-interferon-gamma was acylated with the photoreactive cross-linking reagent, N-succinimidyl-6(4'-azido-2'-nitrophenylamino) hexanoate. Derivatized interferon covalently labeled a cell surface component with an aggregate Mr = 230,000 +/- 7,000 (n = 7). Photoaffinity labeling was judged to be specific for the IFN-gamma receptor as it did not occur in the absence of light or in the presence of excess unlabeled interferon-gamma.

摘要

相似文献

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引用本文的文献

1
The gene for the human immune interferon receptor is located on chromosome 6.人类免疫干扰素受体基因位于6号染色体上。
Proc Natl Acad Sci U S A. 1986 Jan;83(2):384-8. doi: 10.1073/pnas.83.2.384.
2
Interferon receptors.干扰素受体
In Vitro Cell Dev Biol. 1988 Mar;24(3):155-65. doi: 10.1007/BF02623541.