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大鼠红核的电活动及幼年时半侧小脑切除的影响。

Electrical activity in the red nuclei of rats and the effects of hemicerebellectomy at young ages.

作者信息

Gramsbergen A, Schuling F H, Vos J E

出版信息

Behav Brain Res. 1984 Apr;12(1):91-8. doi: 10.1016/0166-4328(84)90208-0.

DOI:10.1016/0166-4328(84)90208-0
PMID:6329241
Abstract

Extracellular activity in the red nuclei in different behavioural states was investigated in control adult rats and in adults rats who had previously undergone a cerebellar hemispherectomy on their 2nd, 5th, 10th or 20th day. In addition to visual analysis, spectra and coherence functions were computed from the signals during quiescence and movements. Preceding and during movements a particular pattern, characterized by a regular rhythm between 7.5 and 8.0 Hz occurs. Inter-rubral coherences are high at the specific pattern frequency. In rats with a cerebellar hemispherectomy - irrespective of the age at lesioning - power spectra from both red nuclei differ markedly from each other during quiescence. When movements occur, rats operated at the 20th day show a pattern in both red nuclei similar to that found in control rats. However, in rats lesioned at the 5th or 10th day the specific pattern frequency is much lower while in rats operated at the 2nd day no specific patterning of red nuclei activity is evident.

摘要

在对照成年大鼠以及在出生后第2、5、10或20天接受过小脑半球切除术的成年大鼠中,研究了不同行为状态下红核的细胞外活动。除了视觉分析外,还计算了静息期和运动期信号的频谱和相干函数。在运动之前和运动期间,会出现一种特定模式,其特征是在7.5至8.0赫兹之间有规律的节律。在特定模式频率下,红核间的相干性很高。在接受过小脑半球切除术的大鼠中——无论损伤时的年龄如何——在静息期,两个红核的功率谱彼此明显不同。当运动发生时,在第20天接受手术的大鼠的两个红核中都出现了一种与对照大鼠相似的模式。然而,在第5天或第10天接受损伤的大鼠中,特定模式频率要低得多,而在第2天接受手术的大鼠中,红核活动没有明显的特定模式。

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