Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation.
作者信息
Huart P, Brasseur R, Goormaghtigh E, Ruysschaert J M
出版信息
Biochim Biophys Acta. 1984 Jun 15;799(2):199-202. doi: 10.1016/0304-4165(84)90296-4.
PMID:6329316
Abstract
We demonstrate here that drugs which inactivate cytochrome c oxidase are able to segregate cardiolipin essential for the enzyme activity, in a separate phase inaccessible for the enzyme. A molecular explanation of the drug-induced aggregation process is proposed.
摘要
Zotero 插件