未成熟大蕉（芭蕉属物种）的抗溃疡活性。
The anti-ulcerogenic activity of the unripe plantain banana (Musa species).
作者信息
Best R, Lewis D A, Nasser N
出版信息
Br J Pharmacol. 1984 May;82(1):107-16. doi: 10.1111/j.1476-5381.1984.tb16447.x.
Abstract
Various preparations of dried unripe plantain banana were found to be anti-ulcerogenic against aspirin-induced ulceration in the rat and were effective both as a prophylactic treatment and in healing ulcers already induced by aspirin. Ripe fruit bananas were inactive. The active factor(s) were water soluble and were concentrated by extraction to approximately three hundred times that in the dried banana powder. The anti-ulcerogenic action of banana preparations appears to be due to their ability to stimulate the growth of gastric mucosa. Aluminium hydroxide, cimetidine, prostaglandin E2, N6, O2-dibutyryl adenosine 3',5' cyclic monophosphate but not 5-hydroxytryptamine were also anti-ulcerogenic when used prophylactically in rats but were ineffective in healing ulcers already formed by aspirin. These substances did not stimulate the growth of gastric mucosa.
摘要
研究发现，各种干燥未成熟芭蕉的制剂对大鼠阿司匹林诱导的溃疡具有抗溃疡作用，无论是作为预防性治疗还是对已由阿司匹林诱导形成的溃疡进行愈合均有效。成熟的香蕉果实则无活性。活性因子是水溶性的，通过提取浓缩后其浓度约为干燥香蕉粉中的三百倍。香蕉制剂的抗溃疡作用似乎是由于它们能够刺激胃黏膜的生长。氢氧化铝、西咪替丁、前列腺素E2、N6，O2 - 二丁酰腺苷3'，5' - 环磷酸单酯，但5 - 羟色胺在大鼠预防性使用时也具有抗溃疡作用，但对已由阿司匹林形成的溃疡愈合无效。这些物质不会刺激胃黏膜的生长。
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