Chandler S H, Baker L L, Goldberg L J
Brain Res. 1984 Jun 11;303(1):91-100. doi: 10.1016/0006-8993(84)90214-2.
Intracellular recordings were carried out in extensor hindlimb motoneurons during L-DOPA-induced fictive locomotion from acute and chronically spinalized cats. It was demonstrated that motoneurons in chronic animals exhibited irregularly occurring, high frequency discharges within a given burst of a spike train, and sporadic membrane potential depolarizations and hyperpolarizations correlated with extensor and flexor nerve filament activity, respectively, during the locomotor cycle. In contrast, motoneurons recorded from acute cats demonstrated smooth membrane potential fluctuation and regularly occurring low frequency spike discharges. These results indicate that the pharmacologically activated central pattern generator (CPG) for locomotion in young adult chronic cats spinalized at two weeks of age produces disorganized locomotor-like patterns in the absence of sensory feedback. It is suggested that the above-mentioned characteristics of membrane potential fluctuations and spike discharges are not due to alterations in the motoneuron membrane properties, but instead are due to changes in the inputs to the motoneurons.
在急性和慢性脊髓损伤猫的L-多巴诱导的虚构运动过程中，对后肢伸肌运动神经元进行了细胞内记录。结果表明，慢性动物的运动神经元在给定的一串动作电位爆发期间表现出不规则出现的高频放电，并且在运动周期中，散在的膜电位去极化和超极化分别与伸肌和屈肌神经纤维活动相关。相比之下，从急性猫记录的运动神经元表现出平滑的膜电位波动和规则出现的低频动作电位放电。这些结果表明，在两周龄时脊髓损伤的年轻成年慢性猫中，由药理学激活的运动中枢模式发生器（CPG）在没有感觉反馈的情况下产生混乱的类似运动的模式。有人提出，上述膜电位波动和动作电位放电的特征不是由于运动神经元膜特性的改变，而是由于运动神经元输入的变化。
