Foulks J G, Morishita L
Can J Physiol Pharmacol. 1984 Apr;62(4):350-5. doi: 10.1139/y84-056.
The local anaesthetic effect of cationic, anionic, and neutral alkyl amphipathic agents was similarly enhanced in an apparently nonspecific way by circumstances which modulate electrostatic interactions (acidity, modification of charged groups at the sarcolemmal surface by group-specific reagents, or changes in the calcium concentration), presumably as the result of secondary effects on the conformation of membrane proteins. However, the selective enhancement of the local anaesthetic effect of alkyl trimethylammonium compounds by perchlorate implies a more specific interaction which may influence the penetration of hydrophobic groups into the membrane interior.
阳离子、阴离子和中性烷基两亲性试剂的局部麻醉作用，在通过调节静电相互作用的环境（酸度、用基团特异性试剂修饰肌膜表面的带电基团或钙浓度变化）下，以一种明显非特异性的方式同样得到增强，这可能是对膜蛋白构象产生次级效应的结果。然而，高氯酸盐对烷基三甲基铵化合物局部麻醉作用的选择性增强意味着一种更特异性的相互作用，这种相互作用可能会影响疏水基团向膜内部的渗透。
