San-Blas G, San-Blas F
Crit Rev Microbiol. 1984;11(2):101-27. doi: 10.3109/10408418409105474.
The approach to this article will be the review of experimental developments achieved in recent years in the fields of biochemistry, molecular biology, ultrastructure, etc. and that have suggested models and hypothesis in order to understand the regulation of the molecular mechanisms involved in fungal differentiation. Since fungal dimorphism has been seen by many investigators as a useful model of differentiation in eukaryotic systems, and also because of the prevalence of dimorphism among human pathogenic fungi, we have considered relevant to review the work done in Mucor, but also in dimorphic pathogenic fungi such as Paracoccidioides brasiliensis, Histoplasma capsulatum, Candida albicans, Blastomyces dermatitidis, and Sporothrix Schenckii. From this point of view, the involvements of cyclic nucleotides, nucleic acid polymerases, synthesis of macromolecules, synthesis of cell wall and less studied factors will be reviewed.
本文的研究方法将是回顾近年来在生物化学、分子生物学、超微结构等领域取得的实验进展，这些进展提出了模型和假设，以理解真菌分化所涉及的分子机制的调控。由于许多研究者将真菌双态性视为真核系统中分化的有用模型，而且由于双态性在人类致病真菌中普遍存在，我们认为回顾在毛霉以及双态致病真菌如巴西副球孢子菌、荚膜组织胞浆菌、白色念珠菌、皮炎芽生菌和申克孢子丝菌中所做的工作是相关的。从这个角度来看，将回顾环核苷酸、核酸聚合酶、大分子合成、细胞壁合成以及较少研究的因素的相关情况。
