替扎尼定在外周组织中对α1和α2肾上腺素能受体的作用。
Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues.
作者信息
Takayanagi I, Konno F, Ishii C, Takemasa T, Yanagida Y, Shimizu M, Mori H, Sugane H
出版信息
Gen Pharmacol. 1984;15(3):239-41. doi: 10.1016/0306-3623(84)90166-6.
PMID:6329897
Abstract
Tizanidine behaved as the partial agonist on the alpha 1-adrenoceptor in high doses (10(-6) -10(-4)M) and as the alpha 2-adrenoceptor agonist in low doses (3 X 10(-9) - 10(-6)M). Tizanidine is about one-third as potent as clonidine in alpha 2-agonistic effect
摘要
替扎尼定在高剂量（10⁻⁶ - 10⁻⁴M）时对α1 - 肾上腺素能受体表现为部分激动剂，在低剂量（3×10⁻⁹ - 10⁻⁶M）时为α2 - 肾上腺素能受体激动剂。替扎尼定的α2激动效应约为可乐定的三分之一。
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