Murphy J F, Jones M, Thompson E N
J Infect. 1984 May;8(3):247-50. doi: 10.1016/s0163-4453(84)94003-9.
Severe oesophageal candidiasis and croup due to involvement of the larynx developed insidiously in a girl aged 20 months. There had been delayed separation of the umbilical cord and repeated infections associated with a defect of neutrophil motility. The significance of the early clinical features was not fully appreciated and the diagnosis considered only when stricture of the oesophagus became evident. She was treated with oral ketoconazole 100 mg daily. After one month's treatment there was striking radiological improvement apart from the persistence of the oesophageal stricture. The croup resolved completely but there was only partial relief of dysphagia because of the residual stricture. We would emphasis that candidiasis should be anticipated and treated vigorously in children with such a defect of neutrophil motility.
一名20个月大的女童隐匿性地患上了严重的食管念珠菌病以及因喉部受累引发的哮吼。该女童存在脐带延迟脱落的情况，且因中性粒细胞运动功能缺陷反复发生感染。早期临床特征的重要性未得到充分认识，直到食管狭窄明显时才考虑进行诊断。她接受了每日口服100毫克酮康唑的治疗。经过一个月的治疗，除食管狭窄持续存在外，放射学检查有显著改善。哮吼完全消退，但由于残留狭窄，吞咽困难仅得到部分缓解。我们要强调的是，对于患有这种中性粒细胞运动功能缺陷的儿童，应预料到念珠菌病的发生并积极进行治疗。
