血管紧张素转换酶的双环内酰胺抑制剂。
Bicyclic lactam inhibitors of angiotensin converting enzyme.
作者信息
Watthey J W, Gavin T, Desai M
出版信息
J Med Chem. 1984 Jun;27(6):816-8. doi: 10.1021/jm00372a022.
PMID:6330355
Abstract
Syntheses of the potent angiotensin converting enzyme inhibitor 1-(carboxymethyl)-3-(mercaptomethyl)-2,3,4,5-tetrahydro-1H-1- benzazep in -2-one (4a) and the corresponding eight-membered ring analogue (4b) are described. The influence of ring size on the inhibitory potencies of these substances is discussed.
摘要
本文描述了强效血管紧张素转换酶抑制剂1-(羧甲基)-3-(巯基甲基)-2,3,4,5-四氢-1H-1-苯并氮杂䓬-2-酮(4a)及相应的八元环类似物(4b)的合成。讨论了环大小对这些物质抑制效力的影响。
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