甾体生成抑制剂。1. 曲洛司坦及相关化合物的肾上腺抑制和阻断活性。
Steroidogenesis inhibitors. 1. Adrenal inhibitory and interceptive activity of trilostane and related compounds.
作者信息
Christiansen R G, Neumann H C, Salvador U J, Bell M R, Schane H P, Creange J E, Potts G O, Anzalone A J
出版信息
J Med Chem. 1984 Jul;27(7):928-31. doi: 10.1021/jm00373a021.
PMID:6330362
Abstract
Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory activity.
摘要
制备了几种孕三烯酮的甲基化衍生物。对C-4或C-4与C-17进行甲基化会将这种相对选择性的肾上腺抑制剂转变为具有增强的卵巢/胎盘抑制活性且肾上腺抑制活性降低的化合物。
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