钙调蛋白和环磷酸腺苷刺激下MAP-2的差异磷酸化作用
Differential phosphorylation of MAP-2 stimulated by calcium-calmodulin and cyclic AMP.
作者信息
Schulman H
出版信息
Mol Cell Biol. 1984 Jun;4(6):1175-8. doi: 10.1128/mcb.4.6.1175-1178.1984.
Abstract
Comparison of cyclic AMP- and calcium-dependent phosphorylation in rat brain cytosol reveals MAP-2 to be a common endogenous substrate. Examination of limited protease digestion patterns indicates that the two kinases phosphorylate MAP-2 at distinct sites and suggests that such phosphorylation may have differential effects on MAP-2 function.
摘要
大鼠脑细胞溶胶中依赖环磷酸腺苷（cAMP）和钙的磷酸化作用比较显示，微管相关蛋白2（MAP-2）是一种常见的内源性底物。对有限蛋白酶消化模式的研究表明，这两种激酶在不同位点使MAP-2磷酸化，提示这种磷酸化可能对MAP-2功能产生不同影响。
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