Munakata K, Okabe I, Morita K
J Pediatr Surg. 1978 Feb;13(1):67-75. doi: 10.1016/s0022-3468(78)80215-2.
It is well-known that some patients exhibiting the symptoms of Hirschsprung's disease are shown to have intramural ganglia in the distal myenteric plexus. Some of them have been described as "pseudo-Hirschsprung's disease". It is likely that a variety of conditions have been included in this group. Using a silver impregnation technique we have made a detailed histologic study of the rectum and large bowel in a number of cases with provisional clinical diagnosis of Hirschsprung's disease but in which rectal biopsy showed small ganglia in Meissner's plexus demonstrated by acetylcholinesterase (Ach-E) staining. Three histologic variations were shown that may be called hypoganglionosis, immaturity of ganglia, and hypogenesis. An attempt is made to relate their clinical picture to the histologic findings.
众所周知，一些表现出先天性巨结肠症状的患者在远端肌间神经丛中显示有壁内神经节。其中一些患者被描述为“假性先天性巨结肠病”。这一组可能包括了多种情况。我们采用银浸染技术，对一些临床初步诊断为先天性巨结肠病但直肠活检显示在Meissner神经丛中有小神经节（经乙酰胆碱酯酶染色证实）的病例的直肠和大肠进行了详细的组织学研究。研究显示了三种组织学变异，可称为神经节减少症、神经节不成熟和发育不全。我们试图将它们的临床表现与组织学发现联系起来。
