Tatsuoka Y, Kato Y, Yoshida K, Imura H
Neurosci Lett. 1984 May 18;46(3):255-60. doi: 10.1016/0304-3940(84)90108-3.
The in vivo effects of anticonvulsants on specific binding of [3H]GABA in the rat brain were examined in male Wistar rats. Acute treatment with phenobarbital increased specific [3H]GABA binding in the cerebral cortex, whereas repeated treatment with phenobarbital failed to change [3H]GABA binding. [3H]GABA binding in the cerebellum was not influenced by phenobarbital administration. Acute treatment with phenytoin produced no change in [3H]GABA binding, whereas repeated treatment with phenytoin caused a significant increase in [3H]GABA binding in the cerebellum, but not in the cerebral cortex. The effects of these anticonvulsants may be due, at least in part, to GABA receptor-mediated mechanisms.
在雄性Wistar大鼠中研究了抗惊厥药对大鼠脑内[3H]GABA特异性结合的体内作用。苯巴比妥急性处理可增加大脑皮质中[3H]GABA的特异性结合，而苯巴比妥反复处理则未能改变[3H]GABA结合。小脑内的[3H]GABA结合不受苯巴比妥给药的影响。苯妥英急性处理对[3H]GABA结合无影响，而苯妥英反复处理导致小脑内[3H]GABA结合显著增加，但大脑皮质中未增加。这些抗惊厥药的作用可能至少部分归因于GABA受体介导的机制。
