头孢甲肟对肠杆菌属头孢菌素酶抑制作用的高效液相色谱研究
[HPLC study of the inhibition of enterobacterial cephalosporinases by cefmenoxime].
作者信息
Pechinot A, Duez J M, Bryskier A, Labia R, Kazmierczak A
出版信息
Pathol Biol (Paris). 1984 May;32(5):386-8.
PMID:6330649
Abstract
High performance liquid chromatography (HPLC) has shown that cefmenoxime and cefotaxime are stable to the cephalosporinase of Enterobacter cloacae P99 , Morganella morganii GN 1510 and Serratia liquefaciens 132. They are significantly resistant to hydrolysis by 100 cephalosporinase units (cephalosporinase production of 10(12) bacterial). Cefmenoxime and cefotaxime are also inhibitors of cephalosporinase at the concentration of 5.10-10 micrograms per 10-10 unit of enzyme.
摘要
高效液相色谱法（HPLC）表明，头孢甲肟和头孢噻肟对阴沟肠杆菌P99、摩根摩根菌GN 1510和液化沙雷菌132的头孢菌素酶稳定。它们对100个头孢菌素酶单位（10¹²个细菌产生的头孢菌素酶）的水解具有显著抗性。头孢甲肟和头孢噻肟在每10⁻¹⁰单位酶5×10⁻¹⁰微克的浓度下也是头孢菌素酶的抑制剂。
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