1982年皮提耶-萨尔佩特里埃医院肠杆菌对头孢噻肟和拉莫三嗪的耐药性

[Resistance of Enterobacteria to cefotaxime and lamoxactam at the Pitié-Salpêtrière Hospital in 1982].

作者信息

Nicolas M H, Jarlier V, Fievet M H, Nguyen J, Truffot C

出版信息

Pathol Biol (Paris). 1984 May;32(5):393-5.

Abstract

Systematic collection of data on every Enterobacteriaceae clinical isolate cultured in the Central Bacteriology Laboratory allowed comparison of the percentage of cefotaxim (CTX) and moxalactam ( MOX ) intermediate or resistant (IR) strains among the 8 199 Enterobacteriaceae isolated in 1982 and the 5 032 Enterobacteriaceae isolated in 1980. In 1982, IR rates were 2% to CTX and 0.6% to MOX . Among the 166 strains IR to CTX, 28% were also IR to MOX . Two strains only were IR to MOX but not to CTX. No E. coli, P. mirabilis or Klebsiella strains IR to CTX or MOX were isolated. On the opposite, percentages of strains IR to CTX or MOX were respectively 2.5 and 0 for indole positive Proteus, 6 and 3.6 for Enterobacter, 7.4 and 0.5 for Serratia and 17.2 and 2.5 for Citrobacter. Strains IR to CTX or MOX represented 3.3%, 2.5% and 1% of Enterobacteriaceae isolated from pus, urine and blood cultures, and 4.7%, 2.2% and 1.3% of those isolated in urology, surgery and medicine. Between 1980 and 1982, there was a simultaneous increase in the consumption of CTX and MOX (10 fold) and in the percentage of Enterobacteriaceae IR to CTX (2 fold); this last involved Serratia (9 fold) more than Citrobacter (3 fold) and spared Enterobacter.

摘要

对中央细菌学实验室培养的每一株肠杆菌科临床分离菌进行系统的数据收集，从而能够比较1982年分离出的8199株肠杆菌科细菌和1980年分离出的5032株肠杆菌科细菌中头孢噻肟（CTX）和莫西沙星（MOX）中介或耐药（IR）菌株的百分比。1982年，对CTX的IR率为2%，对MOX的IR率为0.6%。在166株对CTX耐药的菌株中，28%对MOX也耐药。仅2株对MOX耐药但对CTX不耐药。未分离出对CTX或MOX耐药的大肠杆菌、奇异变形杆菌或克雷伯菌菌株。相反，吲哚阳性变形杆菌对CTX或MOX耐药的菌株百分比分别为2.5%和0，肠杆菌为6%和3.6%，沙雷菌为7.4%和0.5%，柠檬酸杆菌为17.2%和2.5%。从脓液、尿液和血液培养物中分离出的肠杆菌科细菌中，对CTX或MOX耐药的菌株分别占3.3%、2.5%和1%，在泌尿外科、外科和内科分离出的菌株中分别占4.7%、2.2%和1.3%。在1980年至1982年期间，CTX和MOX的消耗量同时增加了10倍，肠杆菌科细菌对CTX耐药的百分比增加了2倍；最后一项中，沙雷菌（9倍）的增加幅度超过柠檬酸杆菌（3倍），而肠杆菌未受影响。