各种休克时脑和肺血管紧张素转换酶活性的变化。

Changes in brain and lung angiotensin converting enzyme activity in various shocks.

作者信息

Koyuncuoğlu H, Güngör M, Hatipoğlu I, Enginar N, Sağduyu H, Sabuncu H

出版信息

Pharmacol Res Commun. 1984 May;16(5):479-84. doi: 10.1016/s0031-6989(84)80016-8.

Abstract

The brain and lung angiotensin converting enzyme (ACE) activities of the rats subjected to haemorrhagic, hypovolemic or endotoxic shock and of the mice immunized and then intravenously challenged with bovine serum albumin were determined by means of a spectrophotometric method. The lung ACE activities of all the shock groups were found significantly higher than those of their Control groups whereas only the brain ACE activities of the rats in endotoxic shock and the mice in anaphylactic shock showed a significant increase compared to their own control values. The results were interpreted as supporting evidence for the idea that peripheral and central renin-angiotensin systems may play a deleterious role in shock.

摘要

采用分光光度法测定了遭受失血性、低血容量性或内毒素性休克的大鼠以及免疫后静脉注射牛血清白蛋白进行攻击的小鼠的脑和肺血管紧张素转换酶（ACE）活性。发现所有休克组的肺ACE活性均显著高于其相应对照组，而仅内毒素性休克大鼠和过敏性休克小鼠的脑ACE活性与其自身对照值相比有显著升高。这些结果被解释为支持外周和中枢肾素-血管紧张素系统可能在休克中起有害作用这一观点的证据。