Characteristics of [3H] propyl beta-carboline-3-carboxylate binding to benzodiazepine receptors in human brain. - Suppr | 超能文献

Characteristics of [3H] propyl beta-carboline-3-carboxylate binding to benzodiazepine receptors in human brain.

作者信息

Chiu P, Chiu S, Mishra R K

出版信息

Res Commun Chem Pathol Pharmacol. 1984 May;44(2):199-213.

Abstract

Characterization of the binding of derivatives of beta-carboline-3-carboxylate, a putative endogenous ligand for benzodiazepine (BZ) receptors, has not previously been attempted in normal human brain. In the present study, we demonstrated saturable, high affinity binding of [3H] propyl beta-carboline-3-carboxylate [3H] PrCC) in normal human frontal cerebral cortex and cerebellum exhibiting pharmacological specificity similar to [3H] diazepam and [3H] flunitrazepam binding. The binding of [3H] PrCC is increased by chloride and GABA, but decreased by divalent cations, especially calcium. The profile of [3H] PrCC binding in human brain reflects specific interaction with BZ/ionophore/GABA receptor complexes.

摘要

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