Boughton B J, Simpson A, Baar S, Ala F, Casson J, Gower J
Resuscitation. 1984 May;12(1):41-5. doi: 10.1016/0300-9572(84)90057-1.
A group of 10 patients with 30-70% burns were given intravenous infusions during the first 48 h following hospital admission either with fresh frozen plasma (FFP) or human plasma protein fraction ( HPPF ). FFP contained 300-400 mg/dl plasma fibronectin whereas none was detectable in HPPF . Circulating plasma fibronectin levels fell quickly in those patients receiving HPPF and levels remained low for 2-3 weeks. In those receiving FFP, plasma fibronectin remained normal during the 48-h transfusion period but fell subsequently. Fibronectin may be an important determinant in the resistance to shock and infections. Consideration should therefore be given to the use of blood products which contain fibronectin and to the monitoring of plasma levels both during the acute and recovery periods after burn injury.
一组10名烧伤面积为30%-70%的患者在入院后的头48小时内接受静脉输注，分别输注新鲜冷冻血浆（FFP）或人血浆蛋白组分（HPPF）。FFP含有300-400mg/dl的血浆纤连蛋白，而HPPF中未检测到。接受HPPF的患者循环血浆纤连蛋白水平迅速下降，并在2-3周内维持在低水平。接受FFP的患者在48小时输血期间血浆纤连蛋白保持正常，但随后下降。纤连蛋白可能是抵抗休克和感染的一个重要决定因素。因此，应考虑使用含有纤连蛋白的血液制品，并在烧伤后的急性期和恢复期监测血浆水平。
