Møller J K, Stenderup A
Scand J Infect Dis. 1984;16(2):223-4. doi: 10.3109/00365548409087147.
The influence of long-term treatment with a low dose of pivmecillinam on the fecal flora was investigated. Before treatment Escherichia coli was detected in about 88% of 30 outpatients with chronic recurrent urinary tract infections, but after 1-2 months only about 55% had detectable E. coli in the intestinal flora. E. coli resistant to mecillinam were not selected during the therapy. A similar group of patients treated with nitrofurantoin showed neither changes in the E. coli flora nor in the resistance pattern.
研究了低剂量匹美西林长期治疗对粪便菌群的影响。治疗前，在30例慢性复发性尿路感染门诊患者中，约88%检测到大肠杆菌，但治疗1 - 2个月后，肠道菌群中仅约55%可检测到大肠杆菌。治疗期间未筛选出对美西林耐药的大肠杆菌。一组用呋喃妥因治疗的类似患者，其大肠杆菌菌群及耐药模式均未发生变化。
