Kimura M, Sato I, Shiratori Y, Sugawara N, Ozawa K, Yamabe H
Acta Pathol Jpn. 1984 Mar;34(2):289-304. doi: 10.1111/j.1440-1827.1984.tb07557.x.
We carried out electron microscopic studies on renal tissues from 9 patients with IgA nephropathy. Electron dense deposits were present in the mesangial area in all cases, subendothelial deposits in 4, and subepithelial deposits in only one. In basement membrane, segmental swelling and rarefaction of basement membrane substance were observed. In some cases the degenerated basement membrane substance protruded through the dilated endothelial fenestration into capillary lumina. Focal splitting, attenuation, mouse eaten appearance, and herniation of basement membrane were seen in a high incidence. Mesangial cells possessed well developed rough endoplasmic reticulums and polysomes. In the peripheral areas of mesangial cell cytoplasm, there was accumulation of electron dense substance and this was occasionally continuously present in the mesangial matrix. There was segmental swelling of endothelial cell cytoplasm, resulting in loss of fenestration. Epithelial cells had well developed rough endoplasmic reticulums and polysomes. Segmental foot process fusion was seen, and these processes, regardless of fusion, became electron denser in the area close to the basement membrane. Multivesiculated bodies were present in all cases in the epithelial cells and in 7 cases in the endothelial cells. Spherical microparticles were present in 3 cases in the urinary space or between the basement membrane and the epithelial cells.
我们对9例IgA肾病患者的肾组织进行了电子显微镜研究。所有病例的系膜区均有电子致密沉积物，4例有内皮下沉积物，仅1例有上皮下沉积物。在基底膜中，观察到基底膜物质的节段性肿胀和稀疏。在某些病例中，退变的基底膜物质通过扩张的内皮窗孔突入毛细血管腔。基底膜的局灶性分裂、变薄、虫蚀样外观和疝形成发生率较高。系膜细胞具有发达的粗面内质网和多核糖体。在系膜细胞质的周边区域，有电子致密物质的积聚，且偶尔持续存在于系膜基质中。内皮细胞胞质有节段性肿胀，导致窗孔消失。上皮细胞有发达的粗面内质网和多核糖体。可见节段性足突融合，且这些足突无论是否融合，在靠近基底膜的区域都变得电子密度更高。所有病例的上皮细胞中均有多囊泡体，7例内皮细胞中有多囊泡体。3例在尿腔或基底膜与上皮细胞之间有球形微粒。
