Hydatidiform mole in a Danish material. Morphology and cytogenetics. A preliminary communication.

Morphologic and cytogenetic analyses were performed on 15 evacuated conceptusses with a tentative diagnosis of hydatidiform mole. Nine of these presented with gross vesicles of which 7 were classified as complete and one as partial mole, the last having the characteristics of both types. Chromosomes from cultured villi were obtained from 7 of the 15 specimens; 3 were diploid and 4 triploid. The diploid cases were complete moles with all chromosomes of paternal origin. The four triploid cases--two partial moles and two abortions--were all paternally derived and caused by dispermy. The observations indicate that some moles share histologic features with both partial and complete moles. Two cases were cytogenetically consistent with but histologically different from partial moles.