Shneĭder M A, Shtil'bans E B, Rachkovskaia L A, Vetlugina L A, Nikitina E T
Antibiotiki. 1984 May;29(5):344-9.
The antiinfluenza activity of roseofungin, a polyenic macrolide antibiotic was studied in vitro on surviving fragments of the chick embryo chorionallantoic membranes and in ovo on growing chick embryos. It was shown that the antibiotic activity against influenza A and B viruses was sufficiently high. The activity of roseofungin against influenza A virus did not differ from that of remantadin, the most active inhibitor of influenza virus reproduction. However, the activity of roseofungin against influenza B virus was an advantage of this antibiotic over remantadin, which had practically no effect on this virus type. A statistically significant protective effect of roseofungin (p less than 0.05) was shown on the animals with experimental influenza. The study on the antiviral activity of roseofungin against the DNA-containing variolovaccine virus revealed that it markedly inhibited the plague reduction. Roseofungin had a pronounced inhibitory effect on cell neoplastic transformation induced by the RNA-containing oncogenic virus of Rous sarcoma.
研究了多烯大环内酯类抗生素玫瑰红菌素的抗流感活性，采用鸡胚绒毛尿囊膜存活片段进行体外实验，并在鸡胚体内对生长中的鸡胚进行实验。结果表明，该抗生素对甲型和乙型流感病毒的活性足够高。玫瑰红菌素对甲型流感病毒的活性与金刚乙胺（流感病毒复制最有效的抑制剂）无差异。然而，玫瑰红菌素对乙型流感病毒的活性是该抗生素相对于金刚乙胺的优势，后者对该病毒类型几乎没有作用。玫瑰红菌素对实验性流感动物显示出具有统计学意义的保护作用（p小于0.05）。对玫瑰红菌素抗含DNA的痘苗病毒的抗病毒活性研究表明，它能显著抑制蚀斑减少。玫瑰红菌素对劳斯肉瘤含RNA的致癌病毒诱导的细胞肿瘤转化有明显的抑制作用。
