Shneĭder M A, Shtil'bans E B, Paleĭ E I, Vil'ner L M, Tereshin I M
Antibiotiki. 1981 Jul;26(7):532-7.
It was shown experimentally that polyenic antibiotics, i. e. amphotericin B and sodium levorin markedly increased the specific immunogenic properties and interferonogenic activity of inactivated influenza virus vaccine prepared with various methods from highly reproductive recombinants. The rate of pneumonia and death from influenza among the vaccinated mice treated with inactivated influenza virus vaccine and one of the polyenic antibiotics was lower than that among the animals treated with the vaccine alone (P less than 0.05). Correlation between the increase in the immunological response, the decrease in the virus reproduction rate in the lungs and addition of the antibiotics into the vaccine was also observed. It is recommended that inactivated influenza virus vaccine be used in conjunction with polyenic antibiotics.
实验表明，多烯类抗生素，即两性霉素B和左制霉素，可显著提高用多种方法从高繁殖性重组体中制备的灭活流感病毒疫苗的特异性免疫原性和干扰素生成活性。用灭活流感病毒疫苗和其中一种多烯类抗生素治疗的接种小鼠中，流感引起的肺炎和死亡率低于仅用疫苗治疗的动物（P<0.05）。还观察到免疫反应增强、肺中病毒繁殖率降低与在疫苗中添加抗生素之间的相关性。建议将灭活流感病毒疫苗与多烯类抗生素联合使用。
