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受Dk限制的抗流感细胞毒性T细胞克隆失去了其两种同种异体反应性中的一种。

Dk-restricted antiinfluenza cytotoxic T-cell clone loses one of its two alloreactivities.

作者信息

Wraith D C

出版信息

Immunogenetics. 1984;20(2):131-9. doi: 10.1007/BF00364485.

DOI:10.1007/BF00364485
PMID:6332067
Abstract

K6, an influenza-specific cytotoxic T (Tc)-cell clone derived from C3H/He mice, was Dk-restricted. Further analysis showed that K6 also recognized Dd and Dq as allotargets. The clonal nature of the three recognition specificities was confirmed by cold-target cell inhibition. After extensive in vitro selection, K6 lost the ability to lyse Dd cells while retaining both other specificities. The role of the Lyt-2 molecule in antigen-specific self-H-2-restricted vs allospecific recognition was investigated by inhibition with the Lyt-2-specific monoclonal antibody 53-6.7. Both activities were proportionately inhibited, indicating that the Lyt-2 molecule is equally important for both recognition specificities of this Tc-cell clone.

摘要

K6是一个从C3H/He小鼠中获得的流感特异性细胞毒性T（Tc）细胞克隆，受Dk限制。进一步分析表明，K6也将Dd和Dq识别为同种异体靶标。通过冷靶细胞抑制证实了这三种识别特异性的克隆性质。经过广泛的体外筛选，K6失去了裂解Dd细胞的能力，同时保留了其他两种特异性。通过用Lyt-2特异性单克隆抗体53-6.7进行抑制，研究了Lyt-2分子在抗原特异性自身H-2限制与同种异体特异性识别中的作用。两种活性均受到成比例的抑制，表明Lyt-2分子对该Tc细胞克隆的两种识别特异性同样重要。

相似文献

1
Dk-restricted antiinfluenza cytotoxic T-cell clone loses one of its two alloreactivities.受Dk限制的抗流感细胞毒性T细胞克隆失去了其两种同种异体反应性中的一种。
Immunogenetics. 1984;20(2):131-9. doi: 10.1007/BF00364485.
2
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引用本文的文献

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Control of immune interferon release by cytotoxic T-cell clones specific for influenza.流感特异性细胞毒性T细胞克隆对免疫干扰素释放的控制
Immunology. 1985 Apr;54(4):607-14.

本文引用的文献

1
Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.由单纯疱疹病毒特异性细胞毒 H-2k T 淋巴细胞介导的抗 H-2Dd 同种反应与 H-2Dk 相关。
Immunogenetics. 1980;10(4):395-404. doi: 10.1007/BF01561589.
2
An influenza specific T-killer clone is restricted to H-2Ld and cross-reacts with Dk region.一种流感特异性杀伤性T细胞克隆受限于H-2Ld，且与Dk区域发生交叉反应。
Immunogenetics. 1982;16(1):83-7. doi: 10.1007/BF00364444.
3
Cytotoxic T-memory cells in virus infection and the specificity of helper T cells.
病毒感染中的细胞毒性T记忆细胞及辅助性T细胞的特异性
Immunology. 1982 Jan;45(1):79-84.
4
Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis.克隆化细胞毒性T淋巴细胞的抗原识别遵循改变自身假说所预测的规则。
J Exp Med. 1982 Jan 1;155(1):111-25. doi: 10.1084/jem.155.1.111.
5
Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.抗小鼠主要组织相容性复合体（MHC）抗原的单克隆抗体。III. 与H-2b单倍型抗原发生反应的杂交瘤抗体揭示了同种型表达的遗传控制。
J Immunol. 1981 Jan;126(1):317-21.
6
Mutations in H-2Kb influence the specificity of alloreactive effector cells included in the repertoire of H-2Db-restricted cytotoxic T lymphocytes against Moloney leukemia virus.H-2Kb基因的突变会影响H-2Db限制性细胞毒性T淋巴细胞库中针对莫洛尼白血病病毒的同种异体反应性效应细胞的特异性。
Immunogenetics. 1983;17(4):427-36. doi: 10.1007/BF00372460.
7
Recognition of Db and Kb gene products by influenza-specific cytotoxic T cells.流感特异性细胞毒性T细胞对Db和Kb基因产物的识别。
Immunogenetics. 1983;17(3):283-94. doi: 10.1007/BF00364412.
8
Neonatal tolerance of major histocompatibility complex antigens alters Ir gene control of the cytotoxic T cell response to vaccinia virus.主要组织相容性复合体抗原的新生儿耐受性改变了Ir基因对细胞毒性T细胞针对痘苗病毒反应的控制。
J Exp Med. 1983 Apr 1;157(4):1324-38. doi: 10.1084/jem.157.4.1324.
9
Antigen recognition by H-2-restricted cytolytic T lymphocytes is not mediated by two independent receptors.H-2 限制性细胞溶解T淋巴细胞的抗原识别不是由两个独立的受体介导的。
J Exp Med. 1984 Jan 1;159(1):330-5. doi: 10.1084/jem.159.1.330.
10
Cross-reactivity of self-HLA-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes for allo-HLA determinants.自身HLA限制的爱泼斯坦-巴尔病毒特异性细胞毒性T淋巴细胞对同种异体HLA决定簇的交叉反应性。
J Exp Med. 1983 Dec 1;158(6):1804-21. doi: 10.1084/jem.158.6.1804.