持续性非卧床腹膜透析相关性腹膜炎中凝固酶阴性葡萄球菌的菌种鉴定及药敏分析

Species identification and antibiotic sensitivity of coagulase-negative staphylococci from CAPD peritonitis.

作者信息

Gruer L D, Bartlett R, Ayliffe G A

出版信息

J Antimicrob Chemother. 1984 Jun;13(6):577-83. doi: 10.1093/jac/13.6.577.

DOI:10.1093/jac/13.6.577

Abstract

Forty-three strains of coagulase-negative staphylococci were obtained from dialysis effluent during 41 episodes of CAPD peritonitis. Eighty per cent of these were found to be Staphylococcus epidermidis but several other species also occurred. A recurrent infection lasting 15 weeks was caused by Staph. haemolyticus. Multiple antibiotic resistance was found to be common. Of 13 antibiotics tested, only vancomycin was active against all strains although most strains were also sensitive to rifampicin, netilmicin and cefamandole. Vancomycin was chosen for the initial treatment of CAPD peritonitis caused by coagulase-negative staphylococci and eradicated the organism in 29 of 30 episodes.

摘要

在41例持续性非卧床腹膜透析（CAPD）腹膜炎发作期间，从透析流出液中分离出43株凝固酶阴性葡萄球菌。其中80%被鉴定为表皮葡萄球菌，但也发现了其他几种菌种。溶血葡萄球菌引起了一次持续15周的复发性感染。发现多重耐药现象很常见。在测试的13种抗生素中，只有万古霉素对所有菌株都有活性，不过大多数菌株对利福平、奈替米星和头孢孟多也敏感。万古霉素被选用于治疗由凝固酶阴性葡萄球菌引起的CAPD腹膜炎，在30次发作中有29次根除了病原体。