N-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）会导致猴子黑质纹状体多巴胺系统的破坏，但不会影响中脑边缘多巴胺系统。 - Suppr

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超能文献

N-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) causes destruction of the nigrostriatal but not the mesolimbic dopamine system in the monkey.

作者信息

Jacobowitz D M, Burns R S, Chiueh C C, Kopin I J

出版信息

Psychopharmacol Bull. 1984 Summer;20(3):416-22.

PMID:6332329

Abstract

摘要

相似文献

N-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) causes destruction of the nigrostriatal but not the mesolimbic dopamine system in the monkey.N-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）会导致猴子黑质纹状体多巴胺系统的破坏，但不会影响中脑边缘多巴胺系统。

Psychopharmacol Bull. 1984 Summer;20(3):416-22.

[Recovery of nigrostriatal and mesolimbic dopaminergic system following administration of ganglioside in MPTP-treated mice].[在MPTP处理的小鼠中给予神经节苷脂后黑质纹状体和中脑边缘多巴胺能系统的恢复]

No To Shinkei. 1990 Nov;42(11):1035-40.

1-methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway.1-甲基-4-苯基吡啶对黑质纹状体多巴胺能通路具有神经毒性。

Nature. 1986;319(6048):56-7. doi: 10.1038/319056a0.

Neuropharmacological manipulations with MPTP.用1-甲基-4-苯基-1,2,3,6-四氢吡啶进行神经药理学操作。

J Neural Transm Suppl. 1986;20:47-63.

Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.依达拉奉（3-甲基-1-苯基-2-吡唑啉-5-酮）是一种自由基清除剂，可预防1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的黑质神经毒性，但对纹状体无此作用。

J Pharmacol Exp Ther. 2007 Jul;322(1):274-81. doi: 10.1124/jpet.106.119206. Epub 2007 Apr 11.

GM1 ganglioside protects against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of nigrostriatal dopamine neurons in the black mouse.GM1神经节苷脂可保护黑小鼠中1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的黑质纹状体多巴胺神经元变性。

Acta Physiol Scand. 1988 Apr;132(4):587-8. doi: 10.1111/j.1748-1716.1988.tb08371.x.

Chronic nicotine treatment partly protects against the 1-methyl-4-phenyl-2,3,6-tetrahydropyridine-induced degeneration of nigrostriatal dopamine neurons in the black mouse.长期尼古丁治疗可部分保护黑小鼠免受1-甲基-4-苯基-2,3,6-四氢吡啶诱导的黑质纹状体多巴胺神经元变性的影响。

Acta Physiol Scand. 1988 Apr;132(4):589-91. doi: 10.1111/j.1748-1716.1988.tb08372.x.

Mesolimbic dopaminergic neurons are not spared by MPTP neurotoxicity in mice.中脑边缘多巴胺能神经元在小鼠中未免受MPTP神经毒性的影响。

Eur J Pharmacol. 1985 Aug 7;114(1):97-100. doi: 10.1016/0014-2999(85)90528-x.

Attenuation of 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine induced nigrostriatal toxicity in mice by N-acetyl cysteine.N-乙酰半胱氨酸减轻1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的小鼠黑质纹状体毒性。

Cell Mol Biol (Noisy-le-grand). 2007 Apr 15;53(1):48-55.

Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies.开发具有强大黑质纹状体毒性的氟化1-甲基-4-苯基-1,2,3,6-四氢吡啶类似物，用于正电子发射断层扫描研究。

J Pharmacol Exp Ther. 1993 Aug;266(2):790-5.

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Selegiline and Parkinson's disease. Protective and symptomatic considerations.

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Modifications of precentral cortex discharge and EMG activity in monkeys with MPTP-induced lesions of DA nigral neurons.用MPTP诱导多巴胺能黑质神经元损伤的猴子的中央前回皮层放电和肌电图活动的改变

Exp Brain Res. 1990;80(1):177-88. doi: 10.1007/BF00228859.

Hypertrophy of dopamine neurons in the primate following ventromedial mesencephalic tegmentum lesion.灵长类动物腹内侧中脑被盖损伤后多巴胺神经元的肥大。

Exp Brain Res. 1991;87(1):232-8. doi: 10.1007/BF00228526.

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