van Kaam F A, de Beer E L, Stienen G J, Blangé T
J Biomech. 1984;17(7):501-11. doi: 10.1016/0021-9290(84)90018-6.
Force responses obtained during constant velocity length changes on skeletal muscle tissue are simulated by means of two cross-bridge models proposed by Huxley and Simmons (1971, Nature 233, 533-538) and by Julian et al. (1974, Biophys. J. 14, 546-562). An implicit method was used for the numerical approximation in the simulations. The simulated force transients due to constant velocity length changes are found to be in qualitative agreement with re-investigated experimental results obtained from the whole sartorius muscle of the frog. A non-linear tension transient is observed, dependent both on amplitude and on velocity of release revealing an inflexion which gives the transient a shoulder shape. When velocity is increased the inflexion occurs earlier and at a lower tension value. A non-linear transient is observed during stretches performed at moderate velocities. Force responses are found to deviate concavely downwards from a linear time course. Simulations, however, predict a rather linear tension transient for comparable velocities. Implications of the experimental findings are discussed for both models.
利用赫胥黎和西蒙斯（1971年，《自然》233卷，533 - 538页）以及朱利安等人（1974年，《生物物理杂志》14卷，546 - 562页）提出的两种横桥模型，对骨骼肌组织在等速长度变化过程中获得的力响应进行了模拟。模拟过程中采用隐式方法进行数值近似。结果发现，由等速长度变化引起的模拟力瞬变与对青蛙整条缝匠肌重新研究得到的实验结果在定性上相符。观察到一种非线性张力瞬变，它既取决于释放的幅度，也取决于释放的速度，呈现出一个拐点，使瞬变具有肩部形状。当速度增加时，拐点出现得更早且张力值更低。在中等速度的拉伸过程中观察到非线性瞬变。力响应被发现从线性时间进程向下凹性偏离。然而，模拟预测在相当的速度下张力瞬变相当线性。针对这两种模型讨论了实验结果的意义。
