Fodstad H, Blom S
Neurochirurgia (Stuttg). 1984 Jul;27(4):115-6. doi: 10.1055/s-2008-1053671.
The authors implanted a diaphragm pacer in a 71-year-old man who had suffered for two years from continuous hiccup of unknown cause with resulting insomnia. Preoperative transcutaneous stimulation of the phrenic nerves in the neck resulted in diaphragm contractions but did not affect his hiccup. Postoperatively, the patient was free of symptoms for two weeks. Electrophrenic stimulation was then initiated and after three days his hiccup disappeared again. After a ten day period without stimulation his hiccup recurred. For ten months the patient has suffered from hiccup only in the day time during which time he has also used the pacer. With a few exceptions he has been free of symptoms and without pacing during the night, which enables him to sleep normally. The effect of phrenic nerve stimulation on hiccup could be due to interference with the abnormal activation of the phrenic nerve, whatever its cause.
作者为一名71岁男性植入了膈起搏器，该患者因不明原因持续打嗝两年，导致失眠。术前对颈部膈神经进行经皮刺激可引起膈肌收缩，但对其打嗝无影响。术后，患者两周无症状。随后开始进行膈神经电刺激，三天后其打嗝再次消失。在无刺激的十天后，打嗝复发。十个月来，患者仅在白天打嗝，在此期间他也使用了起搏器。除了少数例外情况，他在夜间无症状且无需起搏，能够正常睡眠。膈神经刺激对打嗝的作用可能是由于干扰了膈神经的异常激活，无论其原因是什么。
