Kagawa S
Nihon Geka Gakkai Zasshi. 1984 Jun;85(6):513-20.
It has been demonstrated that the renal graft survival was prolonged after blood transfusion. The immunological action of blood transfusion in the host is not clear yet. The effect of blood transfusion on transplanted tumor growth in mice was examined. Using C3H/He (H-2k), AKR (H-2k), C57BL/6 (H-2b), and (C57BL/6xDBA/2)F1 (H-2b,d)mice, mutually different transfusion combinations were prepared. MH134 cells (hepatoma) originated from C3H/He mice or Lewis lung carcinoma cells originated from C57BL/6 mice were grafted beneath the back skin of mice on the second week after transfusion, and size of the tumor was measured. The results showed that 1) blood transfusion among mice with the same H-2 systems had no enhancing effect on grafted tumor growth, 2) blood transfusion among mice with different H-2 systems markedly enhanced the tumor growth, although different in degrees, 3) In the experiments of component transfusions, transfusion of lymphoid cells also enhanced the tumor growth, but not erythrocytes. The results of these experiments clearly showed the differential effects of allogeneic or syngeneic blood transfusion on transplanted tumor growth in mice.
已经证明输血后肾移植的存活时间得以延长。输血在宿主体内的免疫作用尚不清楚。研究了输血对小鼠移植肿瘤生长的影响。使用C3H/He（H-2k）、AKR（H-2k）、C57BL/6（H-2b）和（C57BL/6xDBA/2）F1（H-2b，d）小鼠，制备了相互不同的输血组合。在输血后第二周，将源自C3H/He小鼠的MH134细胞（肝癌）或源自C57BL/6小鼠的Lewis肺癌细胞接种到小鼠背部皮肤下方，并测量肿瘤大小。结果表明：1）具有相同H-2系统的小鼠之间输血对移植肿瘤生长没有促进作用；2）具有不同H-2系统的小鼠之间输血虽然程度不同，但均显著促进肿瘤生长；3）在成分输血实验中，淋巴细胞输血也促进肿瘤生长，但红细胞输血则不然。这些实验结果清楚地表明了同种异体或同基因输血对小鼠移植肿瘤生长的不同影响。
