Davis B K
J Mol Evol. 1978 Feb 21;10(4):325-38. doi: 10.1007/BF01734222.
The rate of increase in the mean polymer formation rate constant during competitive replication by Qbeta RNA variants (Kramer et al., 1974) has been shown to agree statistically with the variance in their formation rate constants. This result demonstrates that Fisher's fundamental theorem of natural selection (Fisher, 1930) can define time variations in the mean rate of synthesis for a heterogeneous population of replicating polymers. It was also revealed that RNA replication, far from equilibrium, accompanied a progressive decrease in the order of the entropy production derivative, with respect to time, that reached a maximum (with the next higher order being zero). Maximization of entropy at equilibrium, in compliance with the second law of thermodynamics, therefore appears as a natural extension of the earlier non-equilibrium pattern of entropy production within the system. The order of the zero-valued entropy production derivative was shown to be determined by the chemical affinity, and its rate of decrease was specified by the mean polymer formation rate constant.
Qβ RNA变体在竞争性复制过程中平均聚合物形成速率常数的增加速率（Kramer等人，1974年）已被证明在统计学上与其形成速率常数的方差一致。这一结果表明，费希尔自然选择基本定理（Fisher，1930年）可以定义复制聚合物异质群体平均合成速率的时间变化。研究还发现，远离平衡的RNA复制伴随着熵产生导数随时间的逐渐降低，该导数达到最大值（下一个更高阶为零）。因此，根据热力学第二定律，平衡态下的熵最大化似乎是系统早期非平衡态熵产生模式的自然延伸。结果表明，零值熵产生导数的阶数由化学亲和力决定，其降低速率由平均聚合物形成速率常数确定。
