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Reduced PLD repair ability in glutathione synthetase deficient human fibroblasts after UV irradiation.

作者信息

Deschavanne P J, Chavaudra N, Debieu D, Malaise E P

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Oct;46(4):375-82. doi: 10.1080/09553008414551551.

DOI:10.1080/09553008414551551
PMID:6334050
Abstract

Using a human cell strain deficient in glutathione synthetase and a related control, the role of glutathione in repair mechanisms has been investigated. UV light has been used in order to avoid the interaction between thiols and free radicals. When potentially lethal damage repair is completed, deficient cells in plateau phase exhibit smaller surviving fractions than do control cells. The ratio of surviving fractions in control/deficient cells is about 2 for the same radiation dose. These results indicate that thiols and especially GSH are involved in repair mechanisms.

摘要

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