Bolnick D A, Bosetti J B, Haynes L W, Walter A E, Sillman A J
Neurotoxicology. 1984 Summer;5(2):67-80.
The effects of cadmium (1.0 to 400.0 microM CdCl2) on the cone photoreceptor's response to light were studied in the superfused bullfrog retina. The effects of cadmium were complex, characterized by a purely excitatory component at the lower levels and an inhibitory component that became evident with 75.0 microM CdCl2. The maximum increase in cone response amplitude due to the excitatory component was about 60% at 100.0 microM CdCl2. At 400.0 microM CdCl2, the highest concentration examined in this study, cone response amplitude was suppressed by about 35%. Both components were dose-dependent. The excitatory component was reversible only at CdCl2 concentrations below 50.0 microM, and irreversible at levels at and above 50.0 microM. The inhibitory component was always reversible. The slope of the dose-response curve describing the excitatory component (0.60) was about twice that describing the inhibitory component (0.31). The effects of cadmium on cone response amplitude are discussed in terms of the most probable sensitive sites.
在离体灌注的牛蛙视网膜中研究了镉（1.0至400.0微摩尔/升氯化镉）对视锥光感受器光反应的影响。镉的影响较为复杂，低浓度时表现为单纯的兴奋成分，75.0微摩尔/升氯化镉时出现明显的抑制成分。兴奋成分使视锥反应幅度最大增加约60%，此时氯化镉浓度为100.0微摩尔/升。本研究中检测的最高浓度400.0微摩尔/升氯化镉时，视锥反应幅度被抑制约35%。两种成分均呈剂量依赖性。兴奋成分仅在氯化镉浓度低于50.0微摩尔/升时可逆，50.0微摩尔/升及以上时不可逆。抑制成分始终可逆。描述兴奋成分的剂量反应曲线斜率（0.60）约为描述抑制成分曲线斜率（0.31）的两倍。根据最可能的敏感位点讨论了镉对视锥反应幅度的影响。
