Danilova A I, Dekhtiareva O S
Probl Endokrinol (Mosk). 1984 Sep-Oct;30(5):29-34.
A total of 200 patients with diabetes mellitus were examined for T and B immunity systems. The T and B lymphocytes were counted, the response of T lymphocytes to PHA and their sensitivity to thymosine and theophylline were determined. The data obtained attest to inhibition of the T immunity system in patients with diabetes mellitus regardless of the ophthalmoscopic appearance of the eye fundus, with this inhibition being most remarkable in subjects without vascular lesions of the retina. Patients with proliferating diabetic retinopathy manifested activation of the B cell component of immunity. Changes in the content and function of T lymphocytes were followed by inhibition of the hormonal activity of the thymus and accumulation in the blood of the theophylline-sensitive T cell population. It is suggested that quantitative and qualitative deficiencies of cellular immunity give rise to the development of immune complex pathology resulting in the formation and progression of diabetic retinopathies.
共对200例糖尿病患者的T和B免疫系统进行了检查。对T和B淋巴细胞进行计数，测定T淋巴细胞对PHA的反应及其对胸腺素和茶碱的敏感性。所获数据证明，无论眼底的检眼镜表现如何，糖尿病患者的T免疫系统均受到抑制，在无视网膜血管病变的患者中这种抑制最为显著。增殖性糖尿病视网膜病变患者表现出免疫的B细胞成分激活。T淋巴细胞含量和功能的变化之后是胸腺激素活性的抑制以及茶碱敏感T细胞群体在血液中的蓄积。提示细胞免疫的定量和定性缺陷导致免疫复合物病理的发展，从而导致糖尿病视网膜病变的形成和进展。
