Perlmuter L C, Hakami M K, Hodgson-Harrington C, Ginsberg J, Katz J, Singer D E, Nathan D M
Am J Med. 1984 Dec;77(6):1043-8. doi: 10.1016/0002-9343(84)90186-4.
A cross-sectional study was conducted to determine whether normal, age-related declines in cognitive function are accelerated in non-insulin-dependent (type II) diabetes mellitus. Study participants ranged in age from 55 to 74 years. Results indicate that cognitive function is inferior in the patients with type II diabetes compared with a comparably aged, nondiabetic control group. On the basis of a series of cognitive tests, it appears that the cognitive impairment is due to a deficiency in memory retrieval rather than to an attentional or encoding deficit. Cognitive performance is poorer in diabetic patients with peripheral neuropathy or elevated hemoglobin A1c levels. The apparent cognitive impairment in aging patients with type II diabetes may complicate adherence to medical regimens.
开展了一项横断面研究，以确定非胰岛素依赖型（II型）糖尿病患者与年龄相关的正常认知功能衰退是否会加速。研究参与者年龄在55至74岁之间。结果表明，与年龄相仿的非糖尿病对照组相比，II型糖尿病患者的认知功能较差。基于一系列认知测试，似乎认知障碍是由于记忆提取不足而非注意力或编码缺陷所致。患有周围神经病变或血红蛋白A1c水平升高的糖尿病患者认知表现更差。老年II型糖尿病患者明显的认知障碍可能会使坚持医疗方案变得复杂。
