Zajtchuk J T, Mihail R, Jewell J S, Dunne M J, Chadwick S G
Arch Otolaryngol. 1984 Dec;110(12):788-91. doi: 10.1001/archotol.1984.00800380018006.
Seventeen subjects were used in this study to measure the long-term effects of low-dose quinine ingestion as correlated with electronystagmographic (ENG) findings in humans. Four subjects served as controls, nine subjects (low-dose group) drank 52.5 mg of quinine per day, and four subjects (high-dose group) drank 105 mg of quinine per day in commercially prepared tonic water. Only the high-dose group showed transient positional testing abnormalities on ENG. In our experiment, the high-dose group ingested one third of the recommended Food and Drug Administration adult daily oral dose of quinine.
本研究选取了17名受试者，以测量低剂量奎宁摄入的长期影响，并将其与人体眼震电图（ENG）检查结果相关联。4名受试者作为对照组，9名受试者（低剂量组）每天饮用含52.5毫克奎宁的市售奎宁水，4名受试者（高剂量组）每天饮用含105毫克奎宁的市售奎宁水。只有高剂量组在ENG的瞬态位置测试中出现异常。在我们的实验中，高剂量组摄入的奎宁量为美国食品药品监督管理局建议的成人每日口服剂量的三分之一。
