Kudriakova S V, Slavina L S, Mitkevich S P, Mazovetskii A G, Romanovskaia G A
Probl Endokrinol (Mosk). 1984 Nov-Dec;30(6):3-6.
The frequency of HLA antigens incidence with due consideration for diabetes type and age of the patient by the disease onset was studied and the index of the relative risk of diabetes development was calculated. In patients with type I diabetes mellitus, a significant increase of B18 antigen incidence and decrease of B7 antigen incidence were observed, as compared to the controls. No association with HLA antigens were detected in type II diabetes. No differences in HLA antigen incidence in type I diabetes mellitus patients who fell ill before 30 and those who fell ill after 30 years of age were recorded. The index of relative risk of the disease development in patients with type I diabetes is higher in the presence of B18 and lower in the presence of B7 antigens.
研究了根据糖尿病类型和患者发病年龄来考虑的HLA抗原发生率，并计算了糖尿病发展的相对风险指数。与对照组相比，在I型糖尿病患者中，观察到B18抗原发生率显著增加，B7抗原发生率降低。在II型糖尿病中未检测到与HLA抗原的关联。记录了30岁之前发病和30岁之后发病的I型糖尿病患者的HLA抗原发生率没有差异。在存在B18抗原的情况下，I型糖尿病患者疾病发展的相对风险指数较高，而在存在B7抗原的情况下则较低。
