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气管移植。III. 近交系大鼠品系气管黏膜上移植抗原的证明

Tracheal transplantation. III. Demonstration of transplantation antigens on the tracheal mucosa of inbred rat strains.

作者信息

Beigel A, Steffens-Knutzen R, Müller B, Schumacher U, Stein H

出版信息

Arch Otorhinolaryngol. 1984;241(1):1-8. doi: 10.1007/BF00457910.

DOI:10.1007/BF00457910
PMID:6335025
Abstract

Tracheal transplants were performed on inbred strains of rats. Monoclonal antibodies were used in combination with the biotin-avidin technique for demonstrating donor-specific RT1 Ac transplantation antigen. Transplantation antigens were predominantly contained in the tracheal mucosal cells. No donor-specific antigens could be found in the mucosa of transplants which survived orthotopic tracheal transplantation for longer than 210 days. This suggests that the mucosa of the transplant is rejected and replaced by a mucosa from the recipient.

摘要

在近交系大鼠上进行了气管移植。单克隆抗体与生物素-抗生物素蛋白技术联合使用,以证明供体特异性RT1 Ac移植抗原。移植抗原主要存在于气管黏膜细胞中。在原位气管移植存活超过210天的移植黏膜中未发现供体特异性抗原。这表明移植的黏膜被排斥,并被受体的黏膜所取代。

相似文献

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Tracheal transplantation. III. Demonstration of transplantation antigens on the tracheal mucosa of inbred rat strains.气管移植。III. 近交系大鼠品系气管黏膜上移植抗原的证明
Arch Otorhinolaryngol. 1984;241(1):1-8. doi: 10.1007/BF00457910.
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Current Solutions for Long-Segment Tracheal Reconstruction.长段气管重建的当前解决方案
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Tracheal transplantation. I. The immunogenic effect of rat tracheal transplants.
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