[Effect of pirprofen and indomethacin on the effects of oxprenolol and furosemide].

The present study reports on the interaction between the non-steroidal antiinflammatory agents pirprofen (Rengasil) and indomethacin with the antihypertensive effects of oxprenolol and the natriuretic effects of furosemide. Pirprofen did not attenuate the antihypertensive action of oxprenolol nor did it reduce the natriuretic activity of furosemide. When indomethacin was given to the same patients an attenuation of oxprenolol's antihypertensive action was observed in four out of seven patients. Furosemide's effects were not affected. It is suggested that there are responders and non-responders to that drug interaction which is also supported by previously published work. During this study clinical-chemical and hematological parameters were also monitored. There were no changes caused by pirprofen indicating the safety of this new compound. For clinical purposes these data suggest that pirprofen--in contrast to indomethacin--can be safely coadministered with beta-blockers and probably other antihypertensive agents.