胎儿能够调节其钙摄取吗？

Can the fetus regulate its calcium uptake?

作者信息

Kuoppala T, Tuimala R, Parviainen M, Koskinen T

出版信息

Br J Obstet Gynaecol. 1984 Dec;91(12):1192-6. doi: 10.1111/j.1471-0528.1984.tb04736.x.

DOI:10.1111/j.1471-0528.1984.tb04736.x

Abstract

To investigate the role of the fetus in vitamin D metabolism concentrations of vitamin D metabolites, 25(OH)D, 24,25(OH)2D and 1,25(OH)2D, were measured in human umbilical artery and vein. There were no differences between artery and vein in 25(OH)D and 24,25(OH)2D levels. 1,25(OH)2D concentrations were statistically significantly higher in the artery than in the vein. It has been shown in animal experiments that 1,25(OH)2D is an important factor in the maintenance of the placental calcium gradient. We suggest that the fetus actively produces 1,25(OH)2D and hence has the capacity to control its calcium influx.

摘要

为研究胎儿在维生素D代谢中的作用，测定了人脐动脉和脐静脉中维生素D代谢产物、25(OH)D、24,25(OH)2D和1,25(OH)2D的浓度。25(OH)D和24,25(OH)2D水平在动脉和静脉之间没有差异。1,25(OH)2D浓度在动脉中显著高于静脉。动物实验表明，1,25(OH)2D是维持胎盘钙梯度的重要因素。我们认为，胎儿可主动产生1,25(OH)2D，因此有能力控制其钙内流。