Knopp J
Endocrinol Exp. 1984 Dec;18(4):203-8.
Adenylate cyclase activity in rat pituitary gland in vitro after the addition of hypothalamic extracts from rats of different age was investigated. Hypothalamic extracts from fetuses, 20 day-old and adult rats significantly increased the adenylate cyclase activity in pituitary of the adult rat incubated in vitro. However, any similar stimulatory effect was not found after the addition of extracts from 1 or 5 day-old rats. These results show possibly age dependent differences in the content of substances which stimulate the adenylate cyclase activity in the hypothalamus.
研究了添加不同年龄大鼠下丘脑提取物后体外培养的大鼠垂体腺苷酸环化酶活性。来自胎儿、20日龄和成年大鼠的下丘脑提取物显著增加了体外培养的成年大鼠垂体中的腺苷酸环化酶活性。然而，添加1日龄或5日龄大鼠的提取物后未发现任何类似的刺激作用。这些结果可能表明下丘脑刺激腺苷酸环化酶活性的物质含量存在年龄依赖性差异。
