Riccardi C, Migliorati G, Giampietri A, Frati L, Herberman B
Int J Tissue React. 1984;6(5):401-8.
We analysed the phenotypic characteristics of mouse NK cells susceptible to boosting activity by T-cell-growth-factor (TCGF) and the characteristics of NK-cell progenitors able to grow in vitro in the presence of TCGF. Our data show that while both the above-mentioned cell populations are Asialo GM-1+, they differ in the expression of Thy 1 alloantigen. In addition, we also analysed the possible regulatory mechanisms capable of influencing the growth of TCGF-sensitive NK-cell progenitors. The data here reported suggest that the growth capability of NK cell progenitors is under the control of the thymus.
我们分析了易受T细胞生长因子（TCGF）增强活性影响的小鼠自然杀伤（NK）细胞的表型特征，以及在TCGF存在下能够在体外生长的NK细胞祖细胞的特征。我们的数据表明，虽然上述两种细胞群体均为无唾液酸GM-1阳性，但它们在Thy 1同种抗原的表达上有所不同。此外，我们还分析了可能影响对TCGF敏感的NK细胞祖细胞生长的调节机制。此处报告的数据表明，NK细胞祖细胞的生长能力受胸腺控制。
