Krippner H, Merle S, Jörgens K, Pirlet K
Z Rheumatol. 1984 Sep-Oct;43(5):265-71.
Antibodies to dsDNA of the IgG-class show a strong association with disease activity in the course of systemic lupus erythematosus (SLE). Of 22 patients with low dsDNA-levels only one had an exacerbation. In 8 patients a rise of IgG-dsDNA antibodies to high levels occurred, followed by an exacerbation in 7 of them. In 6 of these 7 patients the IgG-dsDNA antibodies had a prognostic value by rising into high ranges 2-12 weeks before the exacerbation. IgG-ssDNA antibodies showed only a weak association to the clinical course. IgM antibodies to dsDNA as well as to ssDNA did not correlate with the clinical activity at all.
IgG 类双链 DNA 抗体与系统性红斑狼疮（SLE）病程中的疾病活动密切相关。在 22 例双链 DNA 水平较低的患者中，仅有 1 例病情加重。8 例患者的 IgG 双链 DNA 抗体水平升高至高水平，随后其中 7 例病情加重。在这 7 例患者中的 6 例中，IgG 双链 DNA 抗体在病情加重前 2 - 12 周升高至高水平，具有预后价值。IgG 单链 DNA 抗体与临床病程仅呈弱相关性。针对双链 DNA 以及单链 DNA 的 IgM 抗体与临床活动完全不相关。
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