Foster N L, Chase T N, Mansi L, Brooks R, Fedio P, Patronas N J, Di Chiro G
Ann Neurol. 1984 Dec;16(6):649-54. doi: 10.1002/ana.410160605.
Regional cerebral glucose metabolism, an index of neuronal activity, was compared in 20 patients with Alzheimer's disease and 8 age-matched normal volunteers by positron emission tomography following [18F]2-fluoro-2-deoxy-D-glucose administration. Overall cortical glucose utilization in the Alzheimer's group was 10 to 49% below that of control individuals. The posterior parietal cortex and contiguous portions of posterior temporal and anterior occipital lobes were most severely affected; frontal cortex was relatively spared. This pattern of cortical involvement is consistent with the major clinical features of Alzheimer's disease. Comparison of patients with early and more advanced dementia suggested that a substantial decline in glucose metabolism occurs before cognitive impairment becomes evident; once the patient is symptomatic, however, small additional metabolic decrements are associated with a marked deterioration in intellectual function.
通过在给予[18F]2-氟-2-脱氧-D-葡萄糖后进行正电子发射断层扫描，比较了20例阿尔茨海默病患者和8名年龄匹配的正常志愿者的区域脑葡萄糖代谢（一种神经元活动指标）。阿尔茨海默病组的总体皮质葡萄糖利用率比对照组低10%至49%。顶叶后皮质以及颞叶后部和枕叶前部的相邻部分受影响最严重；额叶皮质相对未受影响。这种皮质受累模式与阿尔茨海默病的主要临床特征一致。对早期和晚期痴呆患者的比较表明，在认知障碍变得明显之前，葡萄糖代谢就会大幅下降；然而，一旦患者出现症状，额外的小代谢下降就会与智力功能的显著恶化相关。
