Vierucci A, Resti M, Appendino C, Rossi M E, De Martino M, Ulivelli A
Pediatr Med Chir. 1984 Jan-Feb;6(1):35-44.
Infants born to HBsAg-positive mothers are at high risk of contracting perinatal hepatitis B infection. The prevention is based on active as well as passive immunoprophylaxis. We have used hepatitis vaccine in 18 newborns of as many HBsAg-positive mothers. Some haematologic and immunologic parameters are here reported. No alterations were observed as to liver function. Immunoglobulin values were normal for age. Auto-antibodies and rheumatoid factor were constantly absent. Immunecomplexes were present in the serum of some infants. The study of T cell subsets and of natural killer cells activity did not reveal any important changes, whereas minor modifications were present in polymorphonuclear leucocyte function. In all infants submitted to vaccination serum conversion was observed a with different antibody levels.
母亲为乙肝表面抗原（HBsAg）阳性的婴儿感染围产期乙型肝炎的风险很高。预防措施基于主动免疫和被动免疫预防。我们对18名母亲为HBsAg阳性的新生儿使用了乙肝疫苗。本文报告了一些血液学和免疫学参数。未观察到肝功能有改变。免疫球蛋白值在相应年龄正常。自身抗体和类风湿因子一直未出现。一些婴儿的血清中存在免疫复合物。对T细胞亚群和自然杀伤细胞活性的研究未发现任何重要变化，而多形核白细胞功能有轻微改变。在所有接种疫苗的婴儿中均观察到血清转化，抗体水平各不相同。
