Biddle W, Ambrus C M, Gastpar H, Ambrus J L
J Med. 1984;15(5-6):355-66.
The xanthine derivative, Trental (pentoxifylline) was found to inhibit several human leukemic and lymphoma cell lines in tissue cultures. Optimal concentrations were less inhibitory for a normal B-lymphocyte cell line then for the neoplastic cell lines. In fact, small concentrations stimulated DNA synthesis in the normal cell line. Trental and beta-interferon appeared to be additive synergists at certain dosages. Possible mechanisms are discussed.
黄嘌呤衍生物己酮可可碱（Trental）在组织培养中可抑制多种人类白血病和淋巴瘤细胞系。最佳浓度对正常B淋巴细胞系的抑制作用比对肿瘤细胞系的抑制作用小。事实上，低浓度可刺激正常细胞系中的DNA合成。己酮可可碱和β-干扰素在某些剂量下似乎具有相加协同作用。文中讨论了可能的作用机制。
