Uno K, Ohara Y, Arakawa M, Kondo T
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
J Microencapsul. 1984 Jan-Mar;1(1):3-8. doi: 10.3109/02652048409031531.
A new method was proposed to prepare monocored water-loaded microcapsules with diameters of 50 microns or larger by making use of the process of interfacial polymer deposition. A solution of ethylcellulose or polystyrene in dichloromethane was added dropwise to an O/W emulsion in which n-hexane was dispersed as fine droplets in aqueous gelatin solution. Successive evaporation of dichloromethane at 40 degrees C and n-hexane at 80 degrees C gave monocored water-loaded ethylcellulose or polystyrene microcapsules. Monocored water-loaded ethylcellulose/polystyrene composite microcapsules were similarly prepared using mixed solutions of the two polymers in dichloromethane instead of ethylcellulose or polystyrene solution. When those mixed solutions which exhibit phase separation were used, the composite microcapsules obtained had a patchwork-like structure in which polystyrene-rich islands are dispersed in the ethylcellulose-rich sea.
提出了一种新方法，通过利用界面聚合物沉积过程制备直径为50微米或更大的单核载水微胶囊。将乙基纤维素或聚苯乙烯的二氯甲烷溶液滴加到O/W乳液中，其中正己烷以细液滴形式分散在明胶水溶液中。在40℃下连续蒸发二氯甲烷，在80℃下连续蒸发正己烷，得到单核载水乙基纤维素或聚苯乙烯微胶囊。使用两种聚合物在二氯甲烷中的混合溶液代替乙基纤维素或聚苯乙烯溶液，同样制备了单核载水乙基纤维素/聚苯乙烯复合微胶囊。当使用呈现相分离的那些混合溶液时，得到的复合微胶囊具有类似拼凑物的结构，其中富含聚苯乙烯的岛状物分散在富含乙基纤维素的基体中。
