Brasseur R, Deleers M
Laboratories of Macromolecules, Faculty of Sciences, Brussels Free University, Belgium.
Pharmacol Res Commun. 1983 Nov;15(10):901-7. doi: 10.1016/s0031-6989(83)80020-4.
Theoretical conformational analysis has been carried out for different hypoglycemic sulfonylurea -Ca complexes. The formed complex has an hydrophobic external surface and a low amphiphilic character. Our results suggest that Calcium may effectively be transported across membranes of Langerhans B cells and that the different biological potencies of the drugs may be due in part to the shape of the different complexes.
已对不同的降血糖磺酰脲类 - 钙复合物进行了理论构象分析。形成的复合物具有疏水的外表面和较低的两亲性。我们的结果表明，钙可能有效地穿过胰岛β细胞膜，并且药物的不同生物活性可能部分归因于不同复合物的形状。
